HAVCR1 ELISA Kit for Human(Homo sapiens) | EIAab.comHAVCR1 ELISA Kit for Human(Homo sapiens)

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Index > Protein center > HAVCR1(Gene name) > Human

HAVCR1 (Gene name),

Hepatitis A virus cellular receptor 1 (Protein name ), HAVR1_HUMAN from NCBI database.

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General Annotation

Antigen Annotation

Predicted Eptitope

Vaild Sequence

Related Databases

Citations (6)

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Gene name:

HAVCR1(KIM1;TIM1;TIMD1);

Protein name:

Hepatitis A virus cellular receptor 1(HAVcr-1);

Alternative:

T-cell immunoglobulin and mucin domain-containing protein 1(TIMD-1);Kidney injury molecule 1(KIM-1);TIM-1(TIM);T-cell membrane protein 1(TIM);

Organism:

Human (Homo sapiens).

General Annotation

Sub Unit:

N/A

Function:

May play a role in T-helper cell development and the regulation of asthma and allergic diseases. Receptor for TIMD4 (By similarity). In case of human hepatitis A virus (HHAV) infection, functions as a cell-surface receptor for the virus. May play a role in kidney injury and repair.

Subcellular Location:

Membrane Single-pass type I membrane protein

Protein Attributes:

Sequence length:

359

Sequence:

50:

100:

150:

200:

250:

300:

350:

359:

IENSLYATD

3D Structure:

N/A

Predicted Eptitope:

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Vaild Sequence:

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Related Databases

Pfam:

PF07686

STRING:

9606.ENSP00000344844

SMR:

Q96D42

String:

Q96D42

UniGene:

Hs.129711

KEGG:

hsa:26762

MIM:

606518

Uniprot:

Q96D42

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ELISA Kit for Human HAVcr-1

Cat.:

E0785m

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96T

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ELISA Kit for Human HAVcr-1

Cat.:

E0785h

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96T

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ELISA Kit for Human HAVcr-1

Cat.:

E0785r

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96T

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CLIA Kit for Human HAVcr-1

Cat.:

U0785h

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96T

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CLIA Kit for Human HAVcr-1

Cat.:

U0785m

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96T

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CLIA Kit for Human HAVcr-1

Cat.:

U0785r

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Looking for manual.

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Packing:

96T

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Polyclonal Antibody for Human HAVcr-1

Cat.:

P0785Rb-h

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human HAVcr-1

Cat.:

P0785Rb-r

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Packing:

40ug/0.2ml

Polyclonal Antibody for Human HAVcr-1

Cat.:

P0785Rb-m

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Packing:

40ug/0.2ml

Monoclonal Antibody for Human HAVcr-1

Protein for Human HAVcr-1

Cat.:

R0785m

Price:

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Packing:

1mg

Purity:

>90%

R&D Technical Data

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Precision

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤3.6%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤6.9%

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤4.3%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤7.8%

Intra-assay Precision (Precision within an assay):Three samples of known concentration were tested twenty times on one plate to assess intra-assay precision.

Intra-Assay CV: ≤4.5%

Inter-assay Precision (Precision between assays):Three samples of known concentration were tested in five separate assays to assess inter-assay precision.

Inter-Assay CV: ≤8.9%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Recovery

Recovery was determined by spiking various levels of HAVcr-1 into serum and plasma .

Sample Type	Average(%)	Recovery Range (%)
Serum	95	92-98
Plasma	89	86-93

Recovery was determined by spiking various levels of HAVcr-1 into serum and plasma .

Sample Type	Average(%)	Recovery Range (%)
Serum	104	94-110
Plasma	96	89-105

Recovery was determined by spiking various levels of HAVcr-1 into serum and plasma .

Sample Type	Average(%)	Recovery Range (%)
Serum	102	95-114
Plasma	96	93-99

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Linearity

The linearity of the kit was assayed by testing samples spiked with appropriate concentration of HAVcr-1 and their serial dilutions. The results were demonstrated by the percentage of calculated concentration to the expected.

Sample	1：2	1:4	1:8	1:16
serum(n=5)	89-93%	89-101%	86-99%	93-102%
EDTA plasma(n=5)	92-104%	88-101%	82-93%	86-91%
heparin plasma(n=5)	86-98%	84-95%	83-92%	90-103%

Sample	1：2	1:4	1:8	1:16
serum(n=5)	89-103%	86-101%	83-99%	97-110%
EDTA plasma(n=5)	97-108%	88-101%	79-102%	89-99%
heparin plasma(n=5)	86-98%	86-99%	94-108%	90-103%

Sample	1：2	1:4	1:8	1:16
serum(n=5)	89-101%	90-105%	93-97%	93-107%
EDTA plasma(n=5)	95-110%	89-97%	94-110%	88-99%
heparin plasma(n=5)	86-99%	88-96%	99-114%	92-105%

For more information, please refer to the manual,Or contact our technical support: tech@eiaab.com.

Citations

[1].

"Acute Renal Failure Following Near-Drowning"

Y Gorelik, S Darawshi, H Yaseen, et al.

From:Kidney International Reports

[2].

"Urinary NGAL and KIM-1: Biomarkers for Assessment of Acute Ischemic Kidney Injury Following Nephron Sparing Surgery"

Zaid Abassi, Amjad Shalabi, Rima Sohotnik, Omri Nativ, Hoda Awad, Bishara Bishara, Victor Frajewicki, Igor Sukhotnik, Abeer Abbasi, Ofer Nativ

From:The Journal of Urology

[3].

"Phosphodiesterase-5 inhibition attenuates early renal ischemia-reperfusion-induced acute kidney injury: assessment by quantitative measurement of..."

Rima Sohotnik, Omri Nativ, Abeer Abbasi, Hoda Awad, Victor Frajewicki, Bishara Bishara, Igor Sukhotnik, Zaher Armaly, Doron Aronson, Samuel N. Heyman, Ofer Nativ, and Zaid Abassi

From:American Physiological Society

[4].

"Urinary NGAL and KIM-1: potential association with histopathologic features in patients with renal cell carcinoma"

A Shalabi, Z Abassi, H Awad, et al.

From:World Journal of Urology

[5].

"Effects of phosphodiesterase-5 inhibitor on ischemic kidney injury during nephron sparing surgery quantitative assessment by NGAL and KIM-1"

Y Lahoud, O Hussein, A Shalabi, et al.

From:World journal of urology

[6].

"Clinical implication of urinary neutrophil gelatinase-associated lipocalin and kidney injury molecule-1 in patients with acute paraquat intoxication"

HW Gil, JO Yang, EY Lee, SY Hong

From:Clinical Toxicology

References

1.

"The human homolog of HAVcr-1 codes for a hepatitis A virus cellular receptor."
Feigelstock D. , Thompson P. , Mattoo P. , Zhang Y. , Kaplan G.G.
J. Virol.72:6621-6628(1998) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [MRNA];FUNCTION AS A HAV RECEPTOR;TISSUE SPECIFICITY
tissue: Liver.
2.

"Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
Ebert L. , Schick M. , Neubert P. , Schatten R. , Henze S. , Korn B.
Submitted (2004-06) to the EMBL/GenBank/DDBJ databases

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-THR-THR-VAL-PRO-157 INS
3.

"The DNA sequence and comparative analysis of human chromosome 5."
Schmutz J. , Martin J. , Terry A. , Couronne O. , Grimwood J. , Lowry S. , Gordon L.A. , Scott D. , Xie G. , Huang W. , Hellsten U. , Tran-Gyamfi M. , She X. , Prabhakar S. , Aerts A. , Altherr M. , Bajorek E. , Black S. , more...
Nature431:268-274(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]
4.

"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res.14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA];VARIANT MET-THR-THR-VAL-PRO-157 INS
tissue: Kidney.
5.

"Immunoglobulin A (IgA) is a natural ligand of hepatitis A virus cellular receptor 1 (HAVCR1), and the association of IgA with HAVCR1 enhances virus-receptor interactions."
Tami C. , Silberstein E. , Manangeeswaran M. , Freeman G.J. , Umetsu S.E. , DeKruyff R.H. , Umetsu D.T. , Kaplan G.G.
J. Virol.81:3437-3446(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: INTERACTION WITH IMMUNOGLUBULIN A
6.

"Tubular kidney injury molecule-1 (KIM-1) in human renal disease."
van Timmeren M.M. , van den Heuvel M.C. , Bailly V. , Bakker S.J. , van Goor H. , Stegeman C.A.
J. Pathol.212:209-217(2007) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: FUNCTION;INDUCTION
7.

"A quantitative atlas of mitotic phosphorylation."
Dephoure N. , Zhou C. , Villen J. , Beausoleil S.A. , Bakalarski C.E. , Elledge S.J. , Gygi S.P.
Proc. Natl. Acad. Sci. U.S.A.105:10762-10767(2008) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]
tissue: Cervix carcinoma.
8.

"Hepatitis A virus link to atopic disease."
McIntire J.J. , Umetsu S.E. , Macaubas C. , Hoyte E.G. , Cinnioglu C. , Cavalli-Sforza L.L. , Barsh G.S. , Hallmayer J.F. , Underhill P.A. , Risch N.J. , Freeman G.J. , DeKruyff R.H. , Umetsu D.T.
Nature425:576-576(2003) [PubMed] [Europe PMC] [Abstract]

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANTS MET-THR-THR-THR-VAL-PRO-157 INS AND THR-195 DEL
9.

Umetsu D.T.
Submitted (2005-09) to the UniProtKB

[15/1/25 17:38] Upload to ab completed in less than a minute: 1 file transferred (13.4 Kb/s) Cited for: VARIANT MET-THR-THR-VAL-PRO-157 INS

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